2-CHLORO-4-METHYL-QUINOLIN-6-OL synthesis
- Product Name:2-CHLORO-4-METHYL-QUINOLIN-6-OL
- CAS Number:41957-91-9
- Molecular formula:C10H8ClNO
- Molecular Weight:193.63
6340-55-2
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41957-91-9
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Yield:-
Reaction Conditions:
in hydrogen bromide;
Steps:
38.a a.
a. 2-chloro-6-hydroxy-4-methyl-quinoline 22.1 g (0.106 mol) of 2-chloro-6-methoxy-4-methyl-quinoline are refluxed for 4 hours in 210 ml of 48% hydrobromic acid. After cooling the precipitate formed is suction filtered, washed and dried. Yield: 20.5 g (100% of theory), Rf value: 0.72 (silica gel; methylene chloride/ethanol=9:1).
References:
US6200976,2001,B1