2-Chloro-4-fluoronitrobenzene synthesis
- Product Name:2-Chloro-4-fluoronitrobenzene
- CAS Number:2106-50-5
- Molecular formula:C6H3ClFNO2
- Molecular Weight:175.54
625-98-9
190 suppliers
$14.00/25g
2106-50-5
175 suppliers
$14.00/1g
Yield:2106-50-5 16.7%
Reaction Conditions:
with sulfuric acid;nitric acid in hexane;benzene
Steps:
37.a (a)
(a) 3-Chloro-4-nitrofluorobenzene m-Chlorofluorobenzene (240 g. 1.85 moles) is added to a mixture of sulfuric acid (185 g. 1.85 moles) and nitric acid (166 g., 1.85 moles) at -5° C. in 3.5 hours, stirred 13 hours, then benzene (200 ml.) and hexane (200 ml.) ae added. The extract is washed with water (1+300 ml.), sodium carbonate solution (1*300 ml.), and water (1*300 ml.), dried and the solvents removed. The residue is distilled to give 138 g. of mixed isomers. The 4-nitro isomer crystallizes and is filtered off to give 3-chloro-4-nitrofluorobenzene (51 g. 16.7%) m.p. 36°-38° C.
References:
Rohm and Haas Company US4330324, 1982, A
611-06-3
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$15.00/25g
2106-50-5
175 suppliers
$14.00/1g
446-35-5
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$5.00/10g
700-37-8
211 suppliers
$9.00/1g
320-98-9
290 suppliers
$8.00/5g
2106-50-5
175 suppliers
$14.00/1g
611-06-3
18 suppliers
$15.00/25g
2106-50-5
175 suppliers
$14.00/1g