2-Bromopyridine-5-carbaldehyde synthesis
- Product Name:2-Bromopyridine-5-carbaldehyde
- CAS Number:149806-06-4
- Molecular formula:C6H4BrNO
- Molecular Weight:186.01
154321-32-1
8 suppliers
inquiry
149806-06-4
419 suppliers
$5.00/1g
Yield:149806-06-4 92%
Reaction Conditions:
with calcium carbonate in water at 105; for 16 h;
Steps:
A.1 Preparation of 6-bromonicotinaldehyde (Ib)
A solution of intermediate Ia (3.650 g, 11.07 mmol), calcium carbonate (2.437 g,24.35 mmol) in water (80m1) was stirred at 105°C for 16 hours. The cooled mixture was diluted with water and extracted with EtOAc twice. The combined organics were washed with water, with saturated solution of NaC1, dried over MgSO4, filtered and evaporated to give intermediate lb (1.890 g, 92%). ‘H NMR (500 MHz, CDC13) ? 10.05 (s, 1H), 8.78(d, J= 2.2 Hz, 1H), 7.98 (dd, J= 8.2, 2.4 Hz, 1H), 7.65 (d, J= 8.2 Hz, 1H).
References:
AB SCIENCE;MOUSSY, Alain;BENJAHAD, Abdellah;PEZ, Didier;SANDRINELLI, Franck;MARTIN, Jason;PICOUL, Willy;CHEVENIER, Emmanuel WO2016/124747, 2016, A1 Location in patent:Page/Page column 58; 59
624-28-2
718 suppliers
$5.00/5g
149806-06-4
419 suppliers
$5.00/1g
101990-45-8
99 suppliers
$44.00/100mg
149806-06-4
419 suppliers
$5.00/1g