2-bromo-N-isopropylacetamide synthesis
- Product Name:2-bromo-N-isopropylacetamide
- CAS Number:75726-96-4
- Molecular formula:C5H10BrNO
- Molecular Weight:180.04
75-31-0
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598-21-0
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75726-96-4
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Yield:75726-96-4 71%
Reaction Conditions:
in dichloromethane at 20; for 1 h;Inert atmosphere;Cooling with ice;Concentration;
Steps:
1.1 Preparation of 2-bromo-N-isopropylacetamide I
(5 mL) and isopropylamine (1.2 mmol) were added in a 25 mL round bottom flask, the rubber stopper was plugged and protected with nitrogen. Bromoacetyl bromide (1 mmol) was added over 2 minutes with stirring in an ice- After 5 min, the mixture was stirred at room temperature for 1 h and then reacted by TLC until the bromoacetyl bromide disappeared. After stirring, the white solid was filtered off and washed with dichloromethane. The solution was washed with dilute hydrochloric acid solution, Methyl chloride extraction of organic layer, saturated brine washing, anhydrous Na2SO4 dry, spin dry,Column chromatography gave 2-bromo-N-isopropylacetamide I as a white solid (71% yield)
References:
CN106916145,2017,A Location in patent:Paragraph 0017; 0035-0038; 0058; 0066
22118-09-8
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75-31-0
439 suppliers
$14.00/25mL
75726-96-4
116 suppliers
$50.00/1g
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75726-96-4
116 suppliers
$50.00/1g