ChemicalBook CAS DataBase List 2-Bromo-5-iodopyridine

2-Bromo-5-iodopyridine synthesis

7synthesis methods

Product Name:2-Bromo-5-iodopyridine
CAS Number:73290-22-9
Molecular formula:C5H3BrIN
Molecular Weight:283.89

223463-14-7 Synthesis

223463-14-7
247 suppliers
$6.00/250mg

73290-22-9
338 suppliers
$6.00/1g

Yield:73290-22-9 79%

Reaction Conditions:

with perfluoroisopropyl iodide;copper;hydroquinone in N,N-dimethyl-formamide at 20; for 24 h;

Steps:

1 4.1. Typical procedure for the iodination of 1a-t by (CF₃)₂CFI
General procedure: (4-Nitrophenyl)boronic acid (0.067 g, 0.4 mmol), copper powder (0.0052 g, 0.08 mmol,), (CF₃)₂CFI (0.178 g, 0.6 mmol), and DMF (2 mL) were placed in a closed tube with a rubber stopper. The mixture was reacted at room temperature equipped with an air balloon for 24 h. The resulting suspension was poured into water and extracted with ethyl acetate. The organic layer was dried over anhydrous Na₂SO₄ and concentrated to dryness. The crude product was purified by flash column chromatography on silica gel using petroleum ether/ethyl acetate = 20: 1 (v/v) as eluent to give 0.086 g of 2j as a light yellow solid (0.35 mmol, 87%).

References:

Liu, Xi-Hai;Leng, Jing;Jia, Su-Jiao;Hao, Jian-Hong;Zhang, Fanglin;Qin, Hua-Li;Zhang, Cheng-Pan [Journal of Fluorine Chemistry,2016,vol. 189,p. 59 - 67]

FullText

20511-12-0 Synthesis