2-Aminopyridin-4-ol synthesis
- Product Name:2-Aminopyridin-4-ol
- CAS Number:33631-05-9
- Molecular formula:C5H6N2O
- Molecular Weight:110.11
10201-73-7
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$8.00/1g
33631-05-9
235 suppliers
$34.75/1g
Yield:33631-05-9 88%
Reaction Conditions:
with L-Selectride in tetrahydrofuran; for 72 h;Reflux;Inert atmosphere;chemoselective reaction;
Steps:
Demethylation of Methoxypyridines; General Procedure:
General procedure: Toa solution of 1 (1.00 mmol) in THF (7.0 mL) was added L-selectride(1 M in THF, 3.0 mL, 3.00 mmol, 3 equiv) under an argonatmosphere. After being refluxed and monitored by TLC, thereaction mixture was quenched with MeOH and evaporated invacuo. The residue was purified by silica gel column chromatographyto give the desired compound 2.
References:
Makino, Kosho;Hasegawa, Yumi;Inoue, Takahide;Araki, Koji;Tabata, Hidetsugu;Oshitari, Tetsuta;Ito, Kiyomi;Natsugari, Hideaki;Takahashi, Hideyo [Synlett,2019,vol. 30,# 8,p. 951 - 954]
19798-80-2
533 suppliers
$6.00/1g
33631-05-9
235 suppliers
$34.75/1g
1026394-00-2
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33631-05-9
235 suppliers
$34.75/1g