2-Amino-5-nitropyridine synthesis
- Product Name:2-Amino-5-nitropyridine
- CAS Number:4214-76-0
- Molecular formula:C5H5N3O2
- Molecular Weight:139.11
504-29-0
554 suppliers
$5.00/5 g
4214-76-0
522 suppliers
$6.00/10g
Yield:4214-76-0 91.67%
Reaction Conditions:
with sulfuric acid;nitric acid in 1,2-dichloro-ethane at 58; for 10 h;Concentration;Temperature;
Steps:
2 (2) Synthesis of 2-amino-5-nitropyridine
2-aminopyridine was added 18.82g (0.2mol) in a reaction vessel, 75.3 g of dichloroethane, stirred and dissolved, and slowly added dropwise below 10 concentrated sulfuric acid / nitric acid fuming mixed acid 45.17g, 60 addition was complete 12 hours, the reaction liquid from light yellow to red wine.After completion of the reaction, cooled to room temperature, washed with water to pH5.8, the organic layer was recovered under reduced pressure dichloroethane, the residue was slowly poured into ice water to precipitate dark yellow precipitate was filtered, washed with water, and dried to give 2-amino-5- nitropyridine 25.83g, HPLC purity of 98.66%, the yield was 91.67%.
References:
The Zhejiang Bio Corp.;Wu, Zhonghua;Zhang, Xiaopeng;Chen, Guicai;Xu, Tianhua;He, Qilei;Wen, Ming;Zhang, Lijia CN105523995, 2016, A Location in patent:Paragraph 0026; 0043; 0044
2530-26-9
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$29.69/1g
57-13-6
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4214-76-0
522 suppliers
$6.00/10g
5418-51-9
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$12.72/1gm:
4487-59-6
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4214-76-0
522 suppliers
$6.00/10g
456-24-6
219 suppliers
$6.00/1g
4214-76-0
522 suppliers
$6.00/10g
2530-26-9
100 suppliers
$29.69/1g
4214-76-0
522 suppliers
$6.00/10g