ChemicalBook CAS DataBase List 2-AMINO-5-IODOBENZAMIDE

2-AMINO-5-IODOBENZAMIDE synthesis

10synthesis methods

Product Name:2-AMINO-5-IODOBENZAMIDE
CAS Number:32658-67-6
Molecular formula:C7H7IN2O
Molecular Weight:262.05

116027-10-2
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Yield:32658-67-6 100%

Reaction Conditions:

with ammonia in DMF (N,N-dimethyl-formamide);water;

Steps:

1.2

2.0 g (6.90 mmol) of the compound obtained in the preceding step was dissolved in approximately 50 ml of DMF, and an excess of aqueous ammonium hydroxide was added. After 10 minutes of stirring, the reaction solution was poured into 100 ml of water, and acidified with concentrated HCl, then extracted with [2*100] ml of EtOAc. The combined organic layer was then concentrated to yield 1. 8 g (100%) of the desired product as an off-white powder. N. M. R [(DMSO-D6) IH 6] (ppm): 6.50 (d, [J=] 8.8Hz, 1H), 6.68 (s, 2H), 7.12 (s, [1H),] 7.33 (dd, [JL] = 8. 8Hz, [J2] = 2. 1Hz, 1H), 7.77 (d, J= 1. 9Hz, 2H).

References:

WO2004/14381,2004,A2 Location in patent:Page/Page column 29-30