ChemicalBook CAS DataBase List 2-Amino-5-chloropyridine-3-carboxylic acid

2-Amino-5-chloropyridine-3-carboxylic acid synthesis

5synthesis methods

Product Name:2-Amino-5-chloropyridine-3-carboxylic acid
CAS Number:58584-92-2
Molecular formula:C6H5ClN2O2
Molecular Weight:172.57

38496-18-3 Synthesis

38496-18-3
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2-Amino-5-chloropyridine-3-carboxylic acid

58584-92-2
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$18.00/250mg

Yield:58584-92-2 93%

Reaction Conditions:

with ammonium hydroxide at 130; for 12 h;Sealed tube;

Steps:

68 2-Amino-6-chloropyridine-3-carboxylic acid
A solution of 2,6-dichloropyridine-3-carboxylic acid (3 g, 0.0157 mol) in aqueous ammonia (30 mL) was heated in a sealed tube at 130°C for 12 h. The reaction mixture was concentrated and the resulting crude solid was triturated with diethyl ether to afford the title compound (2.5 g, 93%). δ_Η (400 MHz, DMSO-de) 8.02 (d, J 8.0 Hz, IH), 7.55 (s, 2H), 6.62 (d, J 8.0 Hz, IH). LCMS: mlz 173 (97.70%)

References:

UCB BIOPHARMA SPRL;BRACE, Gareth Neil;CHOVATIA, Prafulkumar Tulshibhai;FOULKES, Gregory;JOHNSON, James Andrew;JONES, Severine Danielle;KROEPLIEN, Boris;LECOMTE, Fabien Claude;LOKE, Pui Leng;LOWE, Martin Alexander;MANDAL, Ajay;NORMAN, Timothy John;PALMER, Christopher Francis;PéREZ-FUERTES, Yolanda;PORTER, John Robert;SMYTH, Donald;TRANI, Giancarlo;UDDIN, Muhammed;ZHU, Zhaoning WO2016/198400, 2016, A1 Location in patent:Page/Page column 65

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60-35-5 Synthesis