2-AMINO-4-(TRIFLUOROMETHYL)BENZOIC ACID synthesis
- Product Name:2-AMINO-4-(TRIFLUOROMETHYL)BENZOIC ACID
- CAS Number:402-13-1
- Molecular formula:C8H6F3NO2
- Molecular Weight:205.13
320-94-5
229 suppliers
$9.00/1g
402-13-1
167 suppliers
$18.00/5g
Yield:402-13-1 100%
Reaction Conditions:
with hydrogen;palladium 10% on activated carbon in methanol at 20; under 5250.53 Torr; for 2 h;
Steps:
1
Example 1 :; N-(6-Acetyl-2,4-dioxo-7-trifluoromethyl-l,4-dihydro-2H-quinazolin-3-yl)-methanesulfonamide; 2-Amino-4-trifluoromethyl-benzoic acid; A solution of 2-nitro-4-trifluoromethyl-benzoic acid (100 g, 425 mmol) in MeOH (600 mL) was treated with palladium on carbon (10%) and the mixture was stirred at r.t. for 2 h under hydrogen (7 bars). The mixture was then filtered and concentrated in vacuo to give 2-amino-4-trifluoromethyl-benzoic acid (87.2 g, 425 mmol, 100%) as a yellow solid, m.p. 172-173 0C, ESI-MS: m/z 206 [M+H]+.
References:
NOVARTIS AG;NOVARTIS PHARMA GMBH WO2006/108591, 2006, A1 Location in patent:Page/Page column 10; 66
713-41-7
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$50.00/100 mg
402-13-1
167 suppliers
$18.00/5g
778-94-9
193 suppliers
$10.00/5g
402-13-1
167 suppliers
$18.00/5g
98-16-8
387 suppliers
$9.00/5g
402-13-1
167 suppliers
$18.00/5g
400-98-6
245 suppliers
$10.00/5g
402-13-1
167 suppliers
$18.00/5g