ChemicalBook CAS DataBase List 2-Amino-4-cyanopyridine

2-Amino-4-cyanopyridine synthesis

6synthesis methods

Product Name:2-Amino-4-cyanopyridine
CAS Number:223463-02-3
Molecular formula:C6H5Br2NO
Molecular Weight:266.92

2016-99-1 Synthesis

2016-99-1
156 suppliers
$11.00/250mg

223463-02-3
47 suppliers
$325.00/1g

Yield:223463-02-3 98%

Reaction Conditions:

with borane-THF in tetrahydrofuran at 0 - 50; for 0.166667 h;

Steps:

6.1 Step 1: (2,6-Dibromopyridin-4-yl) methanol

After cooling 2,6-dibromoisonicotinic acid (25 g, 89 mmol) dissolved in tetrahydrofuran (THF) (89 mL) to 0 ° C.,Borane THF complex was added dropwise and then the mixture was heated at 50 ° C. for 3 hours. The reaction was cooled, methanol (MeOH) (30 mL) was added and the reaction was then heated to 50 ° C. for 10 minutes. The mixture was then concentrated and chased with an additional 50 mL of MeOH. The residue was partitioned between ethyl acetate and saturated aqueous Na2CO3. The combined organic phases were dried over anhydrous MgSO 4, filtered and concentrated to give the product (23.26 g, 87 mmol, 98% yield).

References:

JP6557436,2019,B1 Location in patent:Paragraph 0393; 0394; 0395