2-Amino-4,6-dimethoxypyrimidine synthesis
- Product Name:2-Amino-4,6-dimethoxypyrimidine
- CAS Number:36315-01-2
- Molecular formula:C6H9N3O2
- Molecular Weight:155.15
67-56-1
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56-05-3
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36315-01-2
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Yield:36315-01-2 91%
Reaction Conditions:
Stage #1:methanol with sodium hydride in tetrahydrofuran for 0.25 h;Inert atmosphere;
Stage #2:2-Amino-4,6-dichloropyrimidine in tetrahydrofuran for 15 h;Inert atmosphere;
Steps:
3.3. General Synthesis Procedure for Substituted 2-Aminopyrimidines Ia-c
General procedure: Intermediates Ia-c were prepared according to the literature [17]. A solution of NaH (0.35 g,14.6 mmol) in dry THF (12 mL) was cooled to 0 °C under N2, then a substituted alcohol (15.2 mmol)was added dropwise. The mixture was stirred for 15 min while maintaining the temperature at 0 °C.Next, 2-amino-4,6-dichloropyrimidine (1.0 g, 6.1 mmol) was added to the solution. The reaction wascontinued at 62 °C for 15 h. Then the mixture was cooled to ambient temperature, and quenchedwith 1 mL of 1 M hydrochloric acid solution. The mixture was diluted with EtOAc (20 mL), washedtwice with a saturated NaHCO3 solution (20 mL) and brine (20 mL), dried with anhydrous Na2SO4and evaporated in vacuo. Finally, the residue was purified by silica gel column chromatography(EtOAc/petroleum ether) to afford compounds Ia-c.
References:
Chen, Peiqi;Song, Xiangmin;Fan, Yongmei;Kong, Weihao;Zhang, Hao;Sun, Ranfeng [Molecules,2018,vol. 23,# 9,art. no. 2203]
13223-25-1
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36315-01-2
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420-04-2
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51534-05-5
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36315-01-2
515 suppliers
$18.60/2.5g