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ChemicalBook CAS DataBase List 2'-Amino-2'-deoxyguanosine
60966-26-9

2'-Amino-2'-deoxyguanosine synthesis

2synthesis methods
174221-86-4 Synthesis
2'-Amino-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)uridine

174221-86-4
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Yield:-

Steps:

Multi-step reaction with 4 steps
1.1: tetrahydrofuran / 20 °C
1.2: MeOH; Et3N / tetrahydrofuran / 1 h
2.1: 747 mg / trichloroacetic acid / acetonitrile / 1 h
3.1: N,O-bis(trimethylsilyl)acetamide / acetonitrile / 0.5 h / Heating
3.2: trimethylsilyl triflate / acetonitrile / 3 h / Heating
3.3: 60 percent / HCl / acetonitrile; H2O
4.1: 95 percent / n-butylamine / ethanol / 55 °C

References:

Dai, Qing;Deb, Shirshendu K.;Hougland, James L.;Piccirilli, Joseph A. [Bioorganic and Medicinal Chemistry,2006,vol. 14,# 3,p. 705 - 713]

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