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ChemicalBook CAS DataBase List 2-ACETAMIDOFLUORENE
53-96-3

2-ACETAMIDOFLUORENE synthesis

8synthesis methods
2-Acetylaminofluorene is produced for research purposes only with an estimated U.S. annual usage of less than 20 lb. It was originally developed as a possible insecticide but has never been used for this purpose after discovery of its carcinogenicity. It is now almost exclusively used in the laboratory studies as a model carcinogen and mutagen.
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Yield: 75%

Reaction Conditions:

in N,N-dimethyl-formamide at 130; for 2 h;

References:

Bhattacharya, Apurba;Purohit, Vikram C.;Suarez, Victor;Tichkule, Ritesh;Parmer, Gaurang;Rinaldi, Frank [Tetrahedron Letters,2006,vol. 47,# 11,p. 1861 - 1864]

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