2-(7-Hydroxy-1-naphthyl)ethylaMine synthesis
- Product Name:2-(7-Hydroxy-1-naphthyl)ethylaMine
- CAS Number:148018-62-6
- Molecular formula:C12H13NO
- Molecular Weight:187.24
1079774-32-5
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148018-62-6
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Yield:148018-62-6 98%
Reaction Conditions:
with ammonium hydroxide;hydrogen in methanol at 40; under 0.375038 Torr;
Steps:
12 Example 12 Preparation of (7-Hydroxy-l-naphthyl)ethanamine
(7-Hydroxy-l-naphthyl)acetonitrile (5 gm) was dissolved in methanol (500 ml), followed by the addition of aqueous ammonia solution (25 ml), Raney Nickel (5 gm). The reaction mixture was hydrogenated with hydrogen gas under 5 kg/m2 pressure at 40°C until completion of the reaction. The reaction mass was cooled to room temperature, followed by filtration and then concentrating the mass to remove methanol to produce 5 gm of (7- hydroxy- l-naphthyl)ethanamine (Yield: 98%; Purity by HPLC: 99.3%).
References:
WO2014/64706,2014,A1 Location in patent:Page/Page column 73
22009-38-7
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148018-62-6
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