ChemicalBook CAS DataBase List 2,7-Dihydroxy-9-fluorenone

2,7-Dihydroxy-9-fluorenone synthesis

12synthesis methods

Product Name:2,7-Dihydroxy-9-fluorenone
CAS Number:42523-29-5
Molecular formula:C13H8O3
Molecular Weight:212.2

14348-75-5 Synthesis

14348-75-5
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$14.00/1g

42523-29-5
257 suppliers
$6.00/1g

Yield:42523-29-5 865 mg

Reaction Conditions:

with lithium hydroxide monohydrate;N₁,N₂-bis(4-hydroxy-2,6-dimethylphenyl)oxalamide;copper(II) acetylacetonate in water;dimethyl sulfoxide at 120; for 4 h;

Steps:

4 Synthesis of 2,7-dihydroxyfluoren-9-one using bis (2,4-pentanedionato) copper (II)

2,7-dibromofluoren-9-one (manufactured by Tokyo Chemical Industry Co., Ltd., 1.35 g, 4.0 mmol),Lithium hydroxide monohydrate (704 mg, 16.8 mmol),Bis (2,4-pentanedionato) copper (II) (53.6 mg, 0.20 mmol),A mixture of N, N'-bis (2,6-dimethyl-4-hydroxyphenyl) oxamide (65.0 mg, 0.20 mmol) and DMSO / water (9.6 mL / 2.4 mL) at 120 ° C. for 4 hours Heated and stirred. After cooling to room temperature, the reaction mixture is diluted with waterFurthermore, 3 M hydrochloric acid is added to adjust the pH to acidic,The resulting red solid was collected by filtration and vacuum dried (100 ° C., overnight).The target 2,7-dihydroxyfluoren-9-one was obtained as a red solid (865 mg, quantitative, HPLC purity: 85.6%).

References:

JP2019/77634,2019,A Location in patent:Paragraph 0106-0108