ChemicalBook CAS DataBase List (2,6-DIMETHYLPYRIDIN-4-YL)METHANOL

(2,6-DIMETHYLPYRIDIN-4-YL)METHANOL synthesis

4synthesis methods

Product Name:(2,6-DIMETHYLPYRIDIN-4-YL)METHANOL
CAS Number:18088-01-2
Molecular formula:C8H11NO
Molecular Weight:137.18

67-56-1 Synthesis

67-56-1
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Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-

1000210-73-0
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18088-01-2
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$77.50/250 mg

Yield: 40%

Reaction Conditions:

with ammonium persulfate in water for 1 h;Reflux;

Steps:

1.1
Lutidine-N-methoxide (2 g, 8 mmol) was dissolved in 25 mL of methanol and heated to reflux. To this mixture a solution of ammonium persulfate (456 mg, 4 mmol) in 3 mL of water was added. The reflux was continued for 1 hour. The crude was cooled to roomtemperature, and pH was adjusted to 7 using 10% NaOH. The crude was filtered and evaporated to dryness. The final compound was purified on silica gel, to obtain 440 mg of the desired intermediate (iic) as a white solid. Yield: 40%. ‘H NMR (400 MHz, Chloroform-d) ?:6.88 (s, 2H), 4.58 (s, 2H), 2.41 (s, 6H). ‘3C NMR (101 MHz, Chloroform-d) ?: 157.78,150.71, 117.80, 63.43, 24.27.

References:

UNIVERSITE DE GENEVE;RANDO, Gianpaolo;WINSSINGER, Nicolas;LINDBERG, Eric;ANZOLA, Marcello WO2018/69470, 2018, A1 Location in patent:Page/Page column 26; 31