2,6-Dichloro-5-fluoro-3-pyridinecarbonitrile synthesis

1synthesis methods

Product Name:2,6-Dichloro-5-fluoro-3-pyridinecarbonitrile
CAS Number:82671-02-1
Molecular formula:C6HCl2FN2
Molecular Weight:190.99

2,6-Dichloro-5-fluoro-3-pyridinecarbonitrile can be used as organic intermediate and pharmaceutical intermediate, mainly used in laboratory research. It can be synthesized by the reaction of 5-fluoro-6-hydroxy-2-oxo-1H-pyridine-3-carboxamide with phosphorus pentachloride at 130℃.

5-fluoro-6-hydroxy-2-oxo-1H-pyridine-3-carboxamide

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2,6-Dichloro-5-fluoro-3-pyridinecarbonitrile

82671-02-1
231 suppliers
$10.00/5g

Yield:82671-02-1 77%

Reaction Conditions:

with phosphorus pentachloride at 130; for 2.5 h;

References:

Miyamoto;Egawa;Matsumoto [Chemical and Pharmaceutical Bulletin,1987,vol. 35,# 6,p. 2280 - 2285]

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2,6-Dichloro-5-fluoro-3-pyridinecarbonitrile Related Search:

3-Cyanopyridine 2-Chloro-5-(chloromethyl)pyridine 2,6-Dichloropyridine 3-CYANO-5-FLUOROPYRIDINE 2,6-Dihydroxypyridine 2,6-Dichloronicotinonitrile 2,6-Dichloro-3-fluoropyridine 2-Chloro-3-fluoro-5-methylpyridine 2-chloro-5-cyanopyridine 2-Chloro-3-fluoropyridine