Yield:53553-05-2 61%

Reaction Conditions:

with chlorosulfonic acid in (2S)-N-methyl-1-phenylpropan-2-amine hydrate;

Steps:

33.A 3-(N-Butylsulfonamidoyl)-2,6-dichlorobenzoic acid and Other Compound of Formula 3

Part A: Under an atmosphere of nitrogen gas, a reaction vessel was charged with 2,6-dichlorobenzoic acid (10 g, 53.55 mmol) (Formula F) and chlorosulfonic acid (3 ml, 472 mmol). The reaction mixture was refluxed for 1 hour and cooled to 10° C. The contents of the reaction vessel were poured slowly into 3 L of ice water. The white solid which precipitated was collected by filtration and dried in vacuo (10 mm) at 35° C. for 48 hours to give 3-(chlorosulfonyl)-2,6-dichlorobenzoic acid (Formula G) (9.2 g, 61% yield).

References:

US5985838,1999,A