2-(4-methylpiperazino)-5-nitrobenzenecarbaldehyde synthesis
2synthesis methods
- Product Name:2-(4-methylpiperazino)-5-nitrobenzenecarbaldehyde
- CAS Number:30742-63-3
- Molecular formula:C12H15N3O3
- Molecular Weight:249.27
Yield:30742-63-3 95%
Reaction Conditions:
with potassium carbonate in N,N-dimethyl-formamide at 50;
Steps:
5.1 Step 1: Preparation of 2- (4-methylpiperazin-1-yl) -5-nitrobenzaldehyde (Int-5-b)
Add 2-fluoro-5-nitrobenzaldehyde (1g, 5.91mmol),1-methylpiperazine (592.3 mg, 5.91 mmol) and potassium carbonate (1.23 g, 8.87 mmol) were added to DMF (5 mL) and reacted at 50 ° C overnight.The reaction solution was cooled, poured into water, filtered, and the solid was dried to obtain the title compound (1.4 g, yield: 95.0%) in this step.
References:
CN110467615,2019,A Location in patent:Paragraph 0220-0224
