2-(4-Bromophenyl)naphthalene synthesis
- Product Name:2-(4-Bromophenyl)naphthalene
- CAS Number:22082-99-1
- Molecular formula:C16H11Br
- Molecular Weight:283.16
589-87-7
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32316-92-0
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22082-99-1
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Yield:22082-99-1 91.11%
Reaction Conditions:
with tetrakis(triphenylphosphine) palladium(0);potassium carbonate in 1,4-dioxane;water at 84 - 88; for 9 h;Inert atmosphere;
Steps:
1.1 Step 1. Preparation of 2-(4-bromophenyl)naphthalene
Under the protection of argon, to a 300mL three-necked flask connected with a mechanical stirrer, condenser, and thermometer, add 2-naphthaleneboronic acid (30.0g),P-bromoiodobenzene (49.35g), Pd(PPh3)4 (4.60g), potassium carbonate (24.11g), dioxane (150ml), water (60ml),After refluxing the reaction at 84-88°C for 9h, the temperature was lowered to room temperature, filtered, and the filter cake was washed with water until neutral (pH=7),After adding 250 ml of toluene to the filter cake under reflux and water separation, it passes through a holding column, the column liquid is recrystallized, and dried to obtain 45.0 g of light yellow solid 2-(4-bromophenyl)naphthalene (ie, intermediate 1), yield 91.11%.
References:
CN110963876,2020,A Location in patent:Paragraph 0044-0048
106-37-6
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32316-92-0
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22082-99-1
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$8.00/250mg
4482-01-3
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32316-92-0
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106-40-1
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22082-99-1
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5419-55-6
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22082-99-1
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1241602-88-9
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22082-99-1
198 suppliers
$8.00/250mg