ChemicalBook CAS DataBase List 2,4,5-Trifluorobenzyl bromide

2,4,5-Trifluorobenzyl bromide synthesis

10synthesis methods

Product Name:2,4,5-Trifluorobenzyl bromide
CAS Number:157911-56-3
Molecular formula:C7H4BrF3
Molecular Weight:225.01

Preparing 2,4,5-Trifluorobenzyl bromide, involves (a) carrying out esterification reaction on 2,4,5-trifluorobenzyl chloride and carboxylate to prepare 2,4,5-trifluorobenzyl ester, (b) hydrolyzing 2,4,5-trifluorobenzyl ester to prepare 2,4,5-trifluorobenzyl alcohol, and (c) brominating 2,4,5-trifluorobenzyl alcohol to prepare target product.

243139-71-1
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$23.00/1g

157911-56-3
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$12.00/1g

Yield:157911-56-3 99%

Reaction Conditions:

with tetrabutylammonium bromide;hydrogen bromide at 100 - 110; for 15 h;Temperature;Reagent/catalyst;

Steps:

1-6 Example 1: Preparation of 2,4,5-trifluorobenzyl bromide

2L four-neck bottle, throw 2,4,5-trifluorobenzyl chloride 180.5g (1mol),675g (4mol) of 48% hydrobromic acid, 9g of tetrabutylammonium bromide, heat up to 100110 and keep reacting for 15h, cool to 2030 for layering,The lower oil layer was washed once with 180.5g deionized water,Dry under reduced pressure and dehydrate to moisture ≤ 0.5% to obtain 223 g of 2,4,5-trifluorobenzyl bromide,GC analysis: 2,4,5-trifluorobenzyl bromide 99.8%, yield 99%.

References:

CN114605223,2022,A Location in patent:Paragraph 0026-0037