2-(3-(HYDROXYMETHYL)PHENYL)ACETONITRILE synthesis
- Product Name:2-(3-(HYDROXYMETHYL)PHENYL)ACETONITRILE
- CAS Number:177665-49-5
- Molecular formula:C9H9NO
- Molecular Weight:147.17
68432-92-8
126 suppliers
inquiry
177665-49-5
11 suppliers
inquiry
Yield:177665-49-5 95.2%
Reaction Conditions:
with methanol;lithium borohydride in tetrahydrofuran at 80; for 3 h;
Steps:
39.1 The first step: the preparation of 2-(3-(hydroxymethyl)phenyl)acetonitrile
The raw material methyl 3-(cyanomethyl)benzoate (500mg, 2.85mmol, 1eq.) was dissolved in tetrahydrofuran (5mL), methanol (183mg, 5.71mmol, 2eq.) was added to the above mixed solution, and then the boron Lithium hydride (124 mg, 5.71 mmol, 2 eq.) was slowly added to the above mixed solution, and the reaction solution was stirred at 80° C. for 3 h. TLC detected the completion of the reaction, added aqueous hydrochloric acid, adjusted pH to 6, extracted with ethyl acetate (20 mL x 2), combined the organic phases, washed with saturated brine (20 mL x 2), then dried with anhydrous sodium sulfate, filtered, concentrated , the target compound (400 mg, 95.2%) was obtained.
References:
WO2022/161420,2022,A1 Location in patent:Page/Page column 108
151-50-8
0 suppliers
$43.36/100g
82072-22-8
73 suppliers
$40.00/100mg
177665-49-5
11 suppliers
inquiry
6515-58-8
155 suppliers
$5.00/250mg
177665-49-5
11 suppliers
inquiry
1129-28-8
248 suppliers
$13.43/1gm:
177665-49-5
11 suppliers
inquiry
99-36-5
216 suppliers
$13.00/5g
177665-49-5
11 suppliers
inquiry