2,3-dihydro-1-oxo-1H-indene-4-carbonitrile synthesis
- Product Name:2,3-dihydro-1-oxo-1H-indene-4-carbonitrile
- CAS Number:60899-34-5
- Molecular formula:C10H7NO
- Molecular Weight:157.17
27916-43-4
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Yield:60899-34-5 73.56%
Reaction Conditions:
with aluminum (III) chloride;sodium chloride at 140; for 2 h;
Steps:
4
In a single-necked bottle, weigh the product 2-cyanophenylpropionic acid (500 mg), aluminum trichloride (15.22 g), and sodium chloride (1.67 g) obtained in Example 3, and stir at a temperature of 140 ° C; Hours, after the reaction is complete; add 20mL of water and 20mL of ethyl acetate, stir and filter, collect the ethyl acetate layer, add 20mL of sodium hydroxide aqueous solution (1mol / L), stir, collect the ethyl acetate layer, and concentrate to obtain330 mg of 4-cyano-1-indanone solid. The purity was 99% and the yield was 73.56%.
References:
Guangdong Dongyangguang Pharmaceutical Co., Ltd.;Su Wei;Xu Guobin;Sun Guodong;Wang Zhongqing;Hu Yanqing;Luo Zhonghua;Huang Fangfang CN110627683, 2019, A Location in patent:Paragraph 0122-0127
954238-31-4
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15115-60-3
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$5.00/1g
60899-34-5
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22115-41-9
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$5.00/5g
60899-34-5
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