2,3-DICHLOROBENZYL BROMIDE synthesis
- Product Name:2,3-DICHLOROBENZYL BROMIDE
- CAS Number:57915-78-3
- Molecular formula:C7H5BrCl2
- Molecular Weight:239.92
38594-42-2
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$12.00/250mg
7789-60-8
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$10.40/25G
57915-78-3
107 suppliers
$9.00/1g
Yield: 83%
Reaction Conditions:
in toluene
Steps:
35.c c)
c)
1-(bromomethyl)-2,3-dichlorobenzene
To a solution of (2,3-dichlorophenyl)methanol (75 g, 0.431 mol), in toluene (800 mL), tribromophosphine (40.7 g, 0.151 mol) was added dropwise at room temperature with stirring.
Then the reaction mixture was stirred at room temperature for 2 h and concentrated.
The resulting residue was neutralized with aq. NaHCO3 and extracted with DCM (300 mL*3).
The organic layer was washed with brine, dried over Na2SO4, filtered and the filtrate was concentrated to provide the titled compound (84.7 g, 83%), as a deep red solid.
References:
GlaxoSmithKline LLC;Lin, Hong;Luengo, Juan Ignacio;Moore, Michael Lee;Qu, Junya;Rivero, Ralph A.;Tedesco, Rosanna;Yu, Hongyi US9096605, 2015, B2
38594-42-2
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$12.00/250mg
57915-78-3
107 suppliers
$9.00/1g
32768-54-0
256 suppliers
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57915-78-3
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$9.00/1g
50-45-3
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$7.00/10g
57915-78-3
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$9.00/1g
2905-54-6
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$9.00/1g
57915-78-3
107 suppliers
$9.00/1g