2,3-Dichlorobenzoyl cyanide synthesis
- Product Name:2,3-Dichlorobenzoyl cyanide
- CAS Number:77668-42-9
- Molecular formula:C8H3Cl2NO
- Molecular Weight:200.02
Yield:77668-42-9 94.2%
Reaction Conditions:
at 160 - 165; for 7 h;
Steps:
6
Example 6: Synthesis of 2,3-dichlorobenzoyl cyanide; A reactor was loaded with 350.0 g of 2,3-dichlorobenzoyl chloride (1.67 moles) and 200.0 g of cuprous cyanide. The mixture was heated to 160-165 0C and stirred at this temperature for 7 hours. The mixture was cooled to 85 0C and 1200 ml of toluene was added to the mixture. The mixture was stirred for 1 hour at 60 0C, cooled to 15 0C and the inorganic salts were filtrated. The solvent toluene was distilled from the filtrate at 55 0C under reduced pressure. The crude product was crystallised from petroleum ether giving 323.3 g of 2,3-dichlorobenzoyl cyanide with an assay of 97.4 %. Yield was 94.2 %.
References:
CALAIRE CHIMIE SAS WO2007/138075, 2007, A1 Location in patent:Page/Page column 14
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