2',3',5'-Tri-O-acetyl-D-adenosine synthesis
- Product Name:2',3',5'-Tri-O-acetyl-D-adenosine
- CAS Number:7387-57-7
- Molecular formula:C16H19N5O7
- Molecular Weight:393.35
2466-76-4
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7387-57-7
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Yield: 74%
Reaction Conditions:
with sodium hydroxide in water; pH=8 at 20; for 4 h;
Steps:
General Nucleoside Acetylation Protocol
General procedure: Nucleoside/nucleotide (2; 100 mM) and N-acetyl imidazole (1a;10 equiv) were dissolved in water (pH 8; adjusted with 4 MNaOH). The solution was incubated at r.t. for 4 h, and NMR spectra were periodically acquired. The product was purified byreverse-phase (C18) flash coumn chromatography (eluted at pH4 with 100 mM NH4HCO2/MeCN = 98:2 to 80:20). The fractions containing 5 were lyophilised to yield a white powder.
References:
Fernández-García, Christian;Powner, Matthew W. [Synlett,2017,vol. 28,# 1,art. no. ST-2016-S0507-C,p. 78 - 83] Location in patent:supporting information
108-24-7
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58-61-7
901 suppliers
$9.00/1g
7387-57-7
131 suppliers
$5.00/250mg
3021-21-4
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7387-57-7
131 suppliers
$5.00/250mg
3021-21-4
11 suppliers
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7387-57-7
131 suppliers
$5.00/250mg
![Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-](/CAS/20210305/GIF/1000210-73-0.gif)
1000210-73-0
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7387-57-7
131 suppliers
$5.00/250mg