2-(2-METHYL-5-NITROPHENYL)ACETONITRILE synthesis

6synthesis methods

Product Name:2-(2-METHYL-5-NITROPHENYL)ACETONITRILE
CAS Number:409082-11-7
Molecular formula:C9H8N2O2
Molecular Weight:176.17

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143-33-9 Synthesis

143-33-9
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Yield:-

Reaction Conditions:

in acetonitrile; for 8 h;Heating / reflux;

Steps:

1

To a solution of crude 11 (141 g, 0.575 mol) in acetonitrile (4 L) is added sodium cyanide (84.4 g, 1.7 mol), and the resulting mixture is heated at reflux for 8 h. The reaction EPO P A T E N TGNF Patent No.: P1274PC10 is cooled to rt and solvent is removed in vacuo. The crude product is dissolved in DCM and filtered. The filtrate is washed with brine and dried over sodium sulfate. After removing solvent in vacuo, the crude product is purified using flash chromatography (ethyl acetate : petroleum ether = 1 : 1). The product 12 is obtained as a yellow solid. ¹H NMR (300MHz, CDCl₃) δ 8.25 (d, J = 2.4 Hz, IH), 8.13 (dd, J = 2.4, 8.1 Hz, IH), 7.41 (d, J = 8.1 Hz, IH), 3.78 (s, 2H), 2.48 (s, 3H).

References:

WO2008/51757,2008,A1 Location in patent:Page/Page column 33-34

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