2,2-DIMETHOXYPROPIONIC ACID METHYL ESTER synthesis
- Product Name:2,2-DIMETHOXYPROPIONIC ACID METHYL ESTER
- CAS Number:10076-48-9
- Molecular formula:C6H12O4
- Molecular Weight:148.16
67-56-1
776 suppliers
$7.29/5ml-f
600-22-6
383 suppliers
$6.00/5g
149-73-5
547 suppliers
$12.00/5g
10076-48-9
61 suppliers
$17.00/1g
Yield: 62%
Reaction Conditions:
with sulfuric acid for 4 h;Reflux;
Steps:
1.1
Svnthesis of S-Methoxy-pyrrolidine-S-carboxylic acid methyl ester Step 1 : Preparation of methyl α, α-dimethoxypropionate The procedure by Ernest Wenkert, et al. (JACS, 1983, 705, 2021 -2029) was followed. A solution of methyl pyruvate (44g), trimethyl orthoformate (62 ml), concentrated H2SO4 (0.2 ml) in MeOH (120 ml) was reluxed for 4 hours. In the next one hour period, solvent (about 80 ml) was distilled out. The reaction mixture was cooled to 10 0C, poured into a KOH solution (1 .2 g KOH in 600 ml water), and extracted with ether (3x). Combined ether extracts were washed with brine and dried (MgSO4). After concentration, the residue was distilled under vacuum to provide the acetal (8BH) (4Og, 62%, 40-43C/1 torr).
References:
SCHERING CORPORATION WO2009/105500, 2009, A1 Location in patent:Page/Page column 215
600-22-6
383 suppliers
$6.00/5g
149-73-5
547 suppliers
$12.00/5g
107-31-3
354 suppliers
$16.00/25mL
10076-48-9
61 suppliers
$17.00/1g
67-56-1
776 suppliers
$7.29/5ml-f
127-17-3
555 suppliers
$5.00/10g
10076-48-9
61 suppliers
$17.00/1g
