ChemicalBook CAS DataBase List (1R,3S)-3-AMinocyclopentanol hydrochloride

(1R,3S)-3-AMinocyclopentanol hydrochloride synthesis

4synthesis methods

Product Name:(1R,3S)-3-AMinocyclopentanol hydrochloride
CAS Number:1279032-31-3
Molecular formula:C5H12ClNO
Molecular Weight:137.61

167465-99-8 Synthesis

Carbamic acid, [(1S,3R)-3-hydroxycyclopentyl]-, 1,1-dimethylethyl ester (9CI)

167465-99-8
108 suppliers
$35.00/100mg

(1R,3S)-3-AMinocyclopentanol hydrochloride

1279032-31-3
166 suppliers
$39.00/100mg

Yield:1279032-31-3 95%

Reaction Conditions:

with hydrogenchloride in 1,4-dioxane at 20; for 2 h;

Steps:

4 Example 4:Compounds of formula V undergo a de Boc reaction to form a salt to give a compound of formula VI
10 g of the compound of formula V is dissolved in 20 mL of dioxane,Add 50 mL of dioxane hydrochloride (4M) and stir at room temperature for 2 h. Spin the reaction solution,100 mL of acetonitrile was beaten, suction filtered, and the filter cake was rinsed with 100 mL of acetonitrile.Dry blast to give 6.4 g of a white solid.The yield was 95%.

References:

Changzhou Pharmaceutical Factory Co., Ltd.;Sun Guangxiang;Zhang Yunran;Sun Haijiang;Wang Minfeng;Tao Weijie;Fu Jun;Ma Xuwei;Li Xingang CN109020911, 2018, A Location in patent:Paragraph 0085; 0086; 0087; 0088; 0089; 0090

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