(1H-PYRROLO[2,3-B]PYRIDIN-5-YL)-METHANOL synthesis
- Product Name:(1H-PYRROLO[2,3-B]PYRIDIN-5-YL)-METHANOL
- CAS Number:849067-97-6
- Molecular formula:C8H8N2O
- Molecular Weight:148.16
849067-90-9
100 suppliers
$85.00/250mg
849067-97-6
70 suppliers
$65.00/50mg
Yield: 76%
Reaction Conditions:
with methanol;sodium tetrahydroborate for 1 h;
Steps:
93
To the solution of lH-pyrrolo[2,3-b]pyridine-5-carbaldehyde (400 mg, 2.73 mmol, 1.0 eq) in MeOH (10 mL) was added sodium borohydride (208 mg, 5.46 mmol, 2.0 eq). The reaction was stirred for 1 h, and then purified via flash chromatography to afford (lH-pyrrolo[2,3-b]pyridin-5-yl)methanol as a white solid (310 mg, 76%).
References:
LIFESCI PHARMACEUTICALS, INC.;MCDONALD, Andrew WO2015/103317, 2015, A1 Location in patent:Page/Page column 175
![1H-PYRROLO[2,3-B]PYRIDINE-5-CARBOXYLIC ACID METHYL ESTER](/CAS/GIF/849067-96-5.gif)
849067-96-5
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$23.00/250mg
849067-97-6
70 suppliers
$65.00/50mg
![1H-PYRROLO[2,3-B]PYRIDINE-5-CARBOXYLIC ACID](/CAS/GIF/754214-42-1.gif)
754214-42-1
145 suppliers
$20.00/100mg
849067-97-6
70 suppliers
$65.00/50mg