ChemicalBook CAS DataBase List 1H-indazole-4-carbonitrile

1H-indazole-4-carbonitrile synthesis

8synthesis methods

Product Name:1H-indazole-4-carbonitrile
CAS Number:861340-10-5
Molecular formula:C8H5N3
Molecular Weight:143.15

557-21-1 Synthesis

557-21-1
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$12.00/5g

186407-74-9 Synthesis

186407-74-9
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$5.00/1g

861340-10-5
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Yield: 119 mg

Reaction Conditions:

with tetrakis(triphenylphosphine) palladium⁽⁰⁾ in 1-methyl-pyrrolidin-2-one at 85; for 17 h;

Steps:

76 Manufacture of 1H-indazole 4-carbonitrile
4-bromo-1H-indazole (100 mg) was melted in N-methyl pyrrolidone (2 ml), a zinc cyanide (60%, 100 mg) and tetrakis (triphenyl phosphine) palladium (88 mg) were added, and it agitated at 85 degrees C for 17 hours. Water was added to the reaction solution and ethyl acetate extracted the object. The organic layer was dried and concentrated in vacuum with anhydrous sodium sulfate. The mark compound (119 mg) was obtained by refining the obtained residue with silica gel column chromatography (column; Hi-FlashTM the amino Column, developing solvent:chloroform / methanol).

References:

SUMITOMO DAINIPPON PHARMA COMPANY LIMITED;IKEDA, JUNYA;NAKAMURA, TAKANORI;OTAKA, HIROMICHI JP2016/28016, 2016, A Location in patent:Paragraph 0286-0287