1H-Benzimidazole-4-carboxylic acid synthesis
- Product Name:1H-Benzimidazole-4-carboxylic acid
- CAS Number:46006-36-4
- Molecular formula:C8H6N2O2
- Molecular Weight:162.15
122-51-0
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603-81-6
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$7.00/250mg
46006-36-4
145 suppliers
$19.00/250mg
Yield: 98%
Reaction Conditions:
at 130;
Steps:
5.1.92.A
A. lH-Benzo[d]imidazole-4-carboxyIic acid.; 2,3-Diaminobenzoic acid (1.0 g, 6.57 mmol) was suspended in triethylorthoformate (20 mL) and heated to 130 0C overnight. Diethyl ether (100 mL) was then added and the resulting precipitate filtered to give a white solid (1.04 g, 6.41 mmol, 98%). 1H NMR (400 MHz, DMSO-rf6) δ 8.22 (s, IH), 7.91 (dd, J = S.0, 1.2, IH), 7.82 (dd, J = 8.0, 1.2, IH), 7.29 (dd, J = 8.0, 7.6, IH); MS (ESI) m/z 163.0 [M+ 1]+.
References:
SIGNAL PHARMACEUTICALS, LLC WO2008/51494, 2008, A1 Location in patent:Page/Page column 132
64-18-6
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$22.12/250ML
603-81-6
186 suppliers
$7.00/250mg
46006-36-4
145 suppliers
$19.00/250mg
64-18-6
1084 suppliers
$22.12/250ML
46006-36-4
145 suppliers
$19.00/250mg
603-81-6
186 suppliers
$7.00/250mg
208772-23-0
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$45.00/10mg
46006-36-4
145 suppliers
$19.00/250mg
606-18-8
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$9.00/1g
46006-36-4
145 suppliers
$19.00/250mg