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ChemicalBook CAS DataBase List 4-(5-methyl-4-phenylisoxazol-3-yl)benzenesulfonamide
181696-12-8

4-(5-methyl-4-phenylisoxazol-3-yl)benzenesulfonamide synthesis

8synthesis methods
181697-19-8 Synthesis
3-(4-BROMO-PHENYL)-5-METHYL-4-PHENYL-ISOXAZOLE

181697-19-8
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4-(5-methyl-4-phenylisoxazol-3-yl)benzenesulfonamide

181696-12-8
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Yield:181696-12-8 46%

Reaction Conditions:

Stage #1: 4-[5-methyl-4-phenylisoxazol-3-yl]bromobenzenewith n-butyllithium in tetrahydrofuran;hexane at -78 - -60; for 0.5 h;
Stage #2: with sulfur dioxide in tetrahydrofuran;hexane; for 1.18333 h;
Stage #3: with sodium acetate;hydroxylamine-O-sulfonic acid in water at 20;

References:

EP1223167,2002,A2 Location in patent:Page 54-55

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