ChemicalBook CAS DataBase List (5-METHOXY-2-METHYL-1H-INDOL-3-YL)-ACETIC ACID ETHYL ESTER

(5-METHOXY-2-METHYL-1H-INDOL-3-YL)-ACETIC ACID ETHYL ESTER synthesis

12synthesis methods

Product Name:(5-METHOXY-2-METHYL-1H-INDOL-3-YL)-ACETIC ACID ETHYL ESTER
CAS Number:17536-38-8
Molecular formula:C14H17NO3
Molecular Weight:247.29

19501-58-7 Synthesis

19501-58-7
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539-88-8 Synthesis

539-88-8
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(5-METHOXY-2-METHYL-1H-INDOL-3-YL)-ACETIC ACID ETHYL ESTER

17536-38-8
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Yield:17536-38-8 76%

Reaction Conditions:

Stage #1: 4-methoxyphenylhydrazine hydrochloride;4-oxopentanoic acid ethyl esterwith sodium acetate;acetic acid for 3 h;Heating / reflux;
Stage #2: with hydrogenchloride;ethanol in 1,4-dioxane; for 15 h;Heating / reflux;

Steps:

24.24a

24a. Ethyl 2-(5-methoxy-2-methylindol-3-yl)acetateA stirred mixture of 4-methoxyphenylhydraζine hydrochloride (26 g, 0.149 mol), ethyl levulinate (21.5 g, 0.149 mol), and sodium acetate (12.2 g, 0.149 mol) in glacial acetic acid (200 mL) was heated at reflux for 3 hours. The reaction mixture was concentrated to dryness. The residue was dissolved in ethanol (120 mL), treated with 4M HCl in 1,4-dioxane (80 mL), and heated at a gentle reflux for 15 hours. The reaction mixture was concentrated to remove the volatiles, and the residue was taken up with EtOAc, washed with water, aqueous K2CO3, and brine. The organic layer was dried over Na₂SO₄, filtered, and concentrated. Chromatography of the residue (1:1 EtOAc:Hexane, silica gel) gave the title compound (28 g, 76% yield) as a viscous oil. ¹H NMR (300 MHz, CDCl₃) 57.83 (br s, IH), 7.06 (d, J= 8.7 Hz, IH), 7.00 (d, J = 2.4 Hz, IH), 6.77-6.73 (m, IH), 4.12 (q, J= 7.1 Hz, 2H), 3.84 (s, 3H), 3.64 (m, 2H), 2.32 (s, 3H), 1.23 (t, J= 7.1 Hz, 3H); Mass Spectrum (API-TIS) mJz 248 (MH⁺)

References:

WO2006/99416,2006,A1 Location in patent:Page/Page column 98

1076-74-0 Synthesis