(-)-4-Chlorobenzhydrylamine synthesis
- Product Name:(-)-4-Chlorobenzhydrylamine
- CAS Number:163837-57-8
- Molecular formula:C13H12ClN
- Molecular Weight:217.69
28022-43-7
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163837-57-8
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Yield: 70%
Reaction Conditions:
with L-Tartaric acid at 30 - 90;Inert atmosphere;
Steps:
1.2
Step 2. 23.00g of L-(+)-tartaric acid is added to a reaction bottle containing 312.28g of water under the protection of nitrogen, and 31.22g of the compound of formula (III) is added dropwise at a temperature of 30 to 35°C. The speed is 10~15g/h. After dripping, the temperature is raised to 85~90 to keep the reaction, until it is completely dissolved. Filter while hot. The filtrate is cooled to 30. To the reaction solution, 30% lye was added dropwise to adjust the pH to 9~10, stirred for 2h, extracted twice with DCM, the organic phases were combined, washed once with saturated brine, dried, and concentrated under reduced pressure at 25°C to obtain (R)-4 -Chlorobenzylamine, detected by GC, yield 70%, purity 98%.
References:
Hunan Jiu Dian Hongyang Pharmaceutical Co., Ltd.;Tan Junhua;Hu Kuang CN110950821, 2020, A Location in patent:Paragraph 0008-0021
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