ChemicalBook CAS DataBase List (4S)-4-Acetamide-5,6-Dihydro-6-Methyl-2-Sulfonamide-Thio[2,3-B]Thiopyran7,7Dioxide

(4S)-4-Acetamide-5,6-Dihydro-6-Methyl-2-Sulfonamide-Thio[2,3-B]Thiopyran7,7Dioxide synthesis

4synthesis methods

Product Name:(4S)-4-Acetamide-5,6-Dihydro-6-Methyl-2-Sulfonamide-Thio[2,3-B]Thiopyran7,7Dioxide
CAS Number:147200-03-1
Molecular formula:C10H14N2O5S3
Molecular Weight:338.42

(S)-6-Methyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-4-one

147086-79-1
105 suppliers
$310.00/250mg

(4S)-4-Acetamide-5,6-Dihydro-6-Methyl-2-Sulfonamide-Thio[2,3-B]Thiopyran7,7Dioxide

147200-03-1
161 suppliers
$18.00/100mg

147128-79-8
6 suppliers
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Yield:-

Steps:

Multi-step reaction with 5 steps
1.1: thionyl chloride; sulfuryl dichloride / 10 h / 28 °C / Inert atmosphere
2.1: ammonia / methanol; acetone / -10 °C / Inert atmosphere
3.1: sodium tungstate (VI) dihydrate / methanol; water / 47 h / 10 - 50 °C / Inert atmosphere
4.1: sodium tetrahydroborate / water; tetrahydrofuran / 2 h / 15 °C / Inert atmosphere
4.2: 2 h / 40 °C
5.1: methanesulfonic acid / water; acetonitrile / 19 h / 10 - 87 °C / Inert atmosphere; Reflux
5.2: 4 h / 7 - 40 °C / pH 7.3

References:

ZACH SYSTEM S.P.A.;VOLPICELLI, Raffaella;NARDI, Antonio;ANDRETTO, Mauro;MUNARI, Ilaria;BRESCELLO, Roberto;SMANIOTTO, Anna;COTARCA, Livius;VERZINI, Massimo WO2014/5943, 2014, A1

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