ChemicalBook CAS DataBase List Carbamic acid, (3-cyanophenyl)-, 1,1-dimethylethyl ester (9CI)

Carbamic acid, (3-cyanophenyl)-, 1,1-dimethylethyl ester (9CI) synthesis

5synthesis methods

Product Name:Carbamic acid, (3-cyanophenyl)-, 1,1-dimethylethyl ester (9CI)
CAS Number:145878-50-8
Molecular formula:C12H14N2O2
Molecular Weight:218.25

24424-99-5 Synthesis

24424-99-5
833 suppliers
$13.50/25G

2237-30-1 Synthesis

2237-30-1
279 suppliers
$13.00/25g

Carbamic acid, (3-cyanophenyl)-, 1,1-dimethylethyl ester (9CI)

145878-50-8
38 suppliers
$74.23/1gm:

Yield:145878-50-8 93.2%

Reaction Conditions:

with triethylamine in tetrahydrofuran; for 48 h;Heating / reflux;

Steps:

15.47

To a solution of 3-amino-benzonitrile (4.7g, 40.0 mmol) in 20OmL THF, was added triethylamine (5.6mL, 40.0 mmol), followed by di-tert-butyl dicarbonate (8.7g, 40.0 mmol). After two days of heating at reflux, the solution was cooled, then partitioned between water and and ethyl acetate. The product was extracted three times with ethyl acetate, washed with aqueous IM HCl and brine, dried over magnesium sulfate, filtered, and concentrated to dryness. The product was purified using silica gel chromatography (elution with 10% hexane/90% ethyl acetate) to provide A (8.3 Ig, 93.2%).

References:

WO2006/44497,2006,A2 Location in patent:Page/Page column 148

24424-99-5 Synthesis

24424-99-5
833 suppliers
$13.50/25G

145878-50-8
38 suppliers
$74.23/1gm:

References