Tert-Butyl 8-Methoxy-5-Oxa-2-Azaspiro[3.4]Oct-7-Ene-2-Carboxylate synthesis
- Product Name:Tert-Butyl 8-Methoxy-5-Oxa-2-Azaspiro[3.4]Oct-7-Ene-2-Carboxylate
- CAS Number:1453315-95-1
- Molecular formula:C12H19NO4
- Molecular Weight:241.28
398489-26-4
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Yield:-
Steps:
Multi-step reaction with 2 steps
1.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere
1.2: 3 h / -78 °C / Inert atmosphere
2.1: potassium tert-butylate; perhydrodibenzo-18-crown-6 / tert-butyl alcohol / 9 h / Inert atmosphere; Reflux
References:
Li, Dong Bo;Rogers-Evans, Mark;Carreira, Erick M. [Organic Letters,2013,vol. 15,# 18,p. 4766 - 4769]