(S)-(2-Amino-1-phenyl-ethyl)-carbamic acid benzyl ester synthesis

9synthesis methods

Product Name:(S)-(2-Amino-1-phenyl-ethyl)-carbamic acid benzyl ester
CAS Number:130406-36-9
Molecular formula:C16H18N2O2
Molecular Weight:270.33

Carbamic acid, [(1S)-2-azido-1-phenylethyl]-, phenylmethyl ester (9CI)

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(S)-(2-Amino-1-phenyl-ethyl)-carbamic acid benzyl ester

130406-36-9
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Yield:130406-36-9 87%

Reaction Conditions:

Stage #1: (S)-2-<(benzyloxycarbonyl)amino>-2-phenyl ethyl azidewith triphenylphosphine in tetrahydrofuran; for 8 h;Reflux;
Stage #2: with water in tetrahydrofuran; for 16 h;Reflux;

References:

Fotaras, Stamatis;Kokotos, Christoforos G.;Kokotos, George [Organic and Biomolecular Chemistry,2012,vol. 10,# 29,p. 5613 - 5619] Location in patent:supporting information; experimental part

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References

20989-17-7
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References