METHYL (S)-2-(TERT-BUTOXYCARBONYLAMINO)-3-(4-IODOPHENYL)PROPANOATE synthesis
- Product Name:METHYL (S)-2-(TERT-BUTOXYCARBONYLAMINO)-3-(4-IODOPHENYL)PROPANOATE
- CAS Number:113850-76-3
- Molecular formula:C15H20INO4
- Molecular Weight:405.23
76757-90-9
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113850-76-3
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$110.00/1g
Yield:113850-76-3 92%
Reaction Conditions:
with phosphorous triiodide in acetonitrile at 0 - 10;Temperature;Solvent;
Steps:
5; 6 Example 5
Add compound III (150 g, 0.5 mol), 1000 mL of acetonitrile to the reaction flask, stir to dissolve, then add 120 mL of PI3 dropwise, control the temperature to be less than 0°C, after the dropwise addition, keep the reaction at 10°C, and monitor the reaction by TLC. After the reaction is over, add 1000 mL of saturated sodium bicarbonate solution, stir, stand for liquid separation, wash the organic layer once with 500 mL of water, dry with anhydrous sodium sulfate, filter, concentrate under reduced pressure, add petroleum ether to make a slurry, filter, and dry to obtain compound II (186.41g, 0.46mol), the yield is 92%, and the purity is 99.4%.
References:
CN112661671,2021,A Location in patent:Paragraph 0043-0044; 0046-0047
24424-99-5
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113850-76-3
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