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1013071-74-3

1-(3-(Hydroxymethyl)-4-morpholinophenyl)pyrrolidin-2-one synthesis

4synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 2 steps
1: AcONa; AcOH / tetrahydrofuran / 1.5 h / 20 °C
2: KOH / ethanol; H2O / 2.5 h / 80 °C

References:

Hirashima, Shintaro;Oka, Takahiro;Ikegashira, Kazutaka;Noji, Satoru;Yamanaka, Hiroshi;Hara, Yoshinori;Goto, Hiroyuki;Mizojiri, Ryo;Niwa, Yasushi;Noguchi, Toru;Ando, Izuru;Ikeda, Satoru;Hashimoto, Hiromasa [Bioorganic and Medicinal Chemistry Letters,2007,vol. 17,# 11,p. 3181 - 3186]