ETHYL 1-(4-FLUOROPHENYL)-5-OXO-2,5-DIHYDRO-1H-1,2,4-TRIAZOLE-3-CARBOXYLATE synthesis

1synthesis methods

Product Name:ETHYL 1-(4-FLUOROPHENYL)-5-OXO-2,5-DIHYDRO-1H-1,2,4-TRIAZOLE-3-CARBOXYLATE
CAS Number:1000573-68-1
Molecular formula:C11H10FN3O3
Molecular Weight:251.21

2295-31-0 Synthesis

2295-31-0
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$6.00/5g

37522-19-3 Synthesis

Ethylchloro[(4-fluorophenyl)hydrazono]acetate

37522-19-3
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$192.00/1g

ETHYL 1-(4-FLUOROPHENYL)-5-OXO-2,5-DIHYDRO-1H-1,2,4-TRIAZOLE-3-CARBOXYLATE

1000573-68-1
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Yield:1000573-68-1 54%

Reaction Conditions:

Stage #1: thiazoline-2,4-dionewith potassium hydroxide in ethanol; for 1 h;Reflux;
Stage #2: [(4-fluorophenyl)-hydrazono]-chloroacetic acid ethyl ester in ethanol; for 1.5 h;Reflux;

References:

Matiychuk, Vasyl S.;Potopnyk, Mykhaylo A.;Luboradzki, Roman;Obushak, Mykola D. [Synthesis,2011,# 11,p. 1799 - 1803] Location in patent:experimental part