![1515-27-1](/CAS/GIF/1515-27-1.gif)
1-METHYLPIPERIDIN-4-ONE OXIME synthesis
- Product Name:1-METHYLPIPERIDIN-4-ONE OXIME
- CAS Number:1515-27-1
- Molecular formula:C6H12N2O
- Molecular Weight:128.17
![1-Methyl-4-piperidone](/CAS/GIF/1445-73-4.gif)
1445-73-4
469 suppliers
$15.00/25g
![1-METHYLPIPERIDIN-4-ONE OXIME](/CAS/GIF/1515-27-1.gif)
1515-27-1
43 suppliers
$45.00/10mg
Yield: 90.1%
Reaction Conditions:
with hydroxylamine in ethanolReflux;
Steps:
1 Step 1
To a solution of 1 -methylpiperidin-4-one (XCII) (5.066 g, 44.77 mmol, 1 eq) in EtOH (45 mL) was added NH2OH (3.422 g, 49.25 mmol, 1.1 eq). The reaction was stirred at reflux overnight. The solvent was evaporated under vacuum and the residue was dissolved in 7N N in MeOH (20 mL). The solvent was again evaporated under vacuum and the residue was washed with CHCE. The solid was filtered and dried to produce 1 -methylpiperidin-4-one oxime (XCIII) as a white solid (5.17 g, 40.33 mmol, 90.1%). ESIMS found C6Hi2N20 mz 129.0 (M+H).
References:
SAMUMED, LLC;KC, Sunil Kumar;MAK, Chi Ching;EASTMAN, Brian Walter;MARAKOVITS, Joseph Timothy;BOLLU, Venkataiah;CAO, Jianguo;MITTAPALLI, Gopi Kumar WO2020/150545, 2020, A1 Location in patent:Paragraph 0213