1-Methyl-4-pyrazole boronic acid pinacol ester synthesis
- Product Name:1-Methyl-4-pyrazole boronic acid pinacol ester
- CAS Number:761446-44-0
- Molecular formula:C10H17BN2O2
- Molecular Weight:208.07
269410-08-4
401 suppliers
$5.00/1g
74-88-4
349 suppliers
$15.00/10g
761446-44-0
365 suppliers
$10.00/1g
Yield:761446-44-0 93%
Reaction Conditions:
with sodium hydride in tetrahydrofuran at 0 - 20; for 4 h;
Steps:
Intermediate 108: 1-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H- pyrazole
To the solution of 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole (0.40 g, 2.06 mmol) in THF (10 mL) was added NaH (0.1.00 g, 4.12 mmol) followed by methyl iodide (0.25 mL, 4.12 mmol) at 0° C and the reaction mixture was stirred at ambient temperature for 4 hr. The reaction was quenched with saturated NH4Cl solution (20 mL) and extracted with ethyl acetate (2 x 50 mL). The combined organic layers were washed with brine (20 mL), dried over sodium sulfate, and distilled under reduced pressure to obtain Intermediate 108 (0.40 g, 93.00%) as yellow viscous liquid.1H NMR (400 MHz, CDCl3) δ ppm 1.31 (s, 12 H), 3.91 (s, 3 H), 7.65 (s, 1 H), 7.77 (s, 1 H). LCMS (Method-D): retention time 1.58 min, [M+1] 209.1.
References:
WO2018/93569,2018,A1 Location in patent:Page/Page column 189
15803-02-8
344 suppliers
$5.00/1g
73183-34-3
587 suppliers
$6.00/5g
761446-44-0
365 suppliers
$10.00/1g
76-09-5
384 suppliers
$10.00/1g
847818-55-7
159 suppliers
$21.21/1gm:
761446-44-0
365 suppliers
$10.00/1g
39806-90-1
232 suppliers
$9.00/5g
61676-62-8
326 suppliers
$11.19/5G
761446-44-0
365 suppliers
$10.00/1g
15803-02-8
344 suppliers
$5.00/1g
76-09-5
384 suppliers
$10.00/1g
761446-44-0
365 suppliers
$10.00/1g