ChemicalBook CAS DataBase List 1-METHYL-3-PHENYL-1H-PYRAZOLE-5-CARBOXYLIC ACID

1-METHYL-3-PHENYL-1H-PYRAZOLE-5-CARBOXYLIC ACID synthesis

7synthesis methods

Product Name:1-METHYL-3-PHENYL-1H-PYRAZOLE-5-CARBOXYLIC ACID
CAS Number:10250-64-3
Molecular formula:C11H10N2O2
Molecular Weight:202.21

ETHYL 1-METHYL-3-PHENYL-1H-PYRAZOLE-5-CARBOXYLATE

10250-63-2
67 suppliers
$49.00/1g

1-METHYL-3-PHENYL-1H-PYRAZOLE-5-CARBOXYLIC ACID

10250-64-3
77 suppliers
$21.00/100mg

Yield: 93.1%

Reaction Conditions:

with sodium hydroxide in methanol at 20; for 2 h;

Steps:

8.2 Step2: Preparation of Compound 1-3
To a solution of 1-2 (247.5 mg, 1.1 mmol) in MeOH (5 mL) was added sodium hydroxide solution (10 mL, 4 M). The reaction mixture was stirred at room temperature for 2 hours and concentrated under reduced pressure to remove MeOH. The aqueous phase was acidified with aqueous HCl (1 M) till pH=3 and the mixture was extracted with EtOAc, dried with anhydrous Na₂SO₄, filtered and concentrated to give the crude product. The crude product was purified by silica gel chromatography eluted to give product 1-3 (207.0 mg, 93.1%). MS m/z [ESI]: 203.1 [M+1].

References:

SUZHOU SINOVENT PHARMACEUTICALS CO., LTD.;WANG, Yonghui;ZHU, Yan;ZHOU, Juan;GAO, Yujun;WANG, Shiqun;WANG, Dong;LIU, Wandeng;SHEN, Ximing;HONG, Binbin;LIU, Tao;WU, Yaodong;LI, Chunqi US2018/271846, 2018, A1 Location in patent:Paragraph 0176; 0180; 0181