1-METHOXY-4-(METHYLTHIO)BENZENE synthesis
- Product Name:1-METHOXY-4-(METHYLTHIO)BENZENE
- CAS Number:1879-16-9
- Molecular formula:C8H10OS
- Molecular Weight:154.23
624-92-0
352 suppliers
$20.62/5 mL
696-62-8
356 suppliers
$5.00/1g
1879-16-9
125 suppliers
$10.00/1g
Yield:1879-16-9 78%
Reaction Conditions:
with tetrabutylammomium bromide;copper(II) acetate monohydrate;potassium hydroxide in water at 100; for 12 h;Catalytic behavior;Sealed tube;Reagent/catalyst;Temperature;
Steps:
(Het)aryl Methyl Sulfides; General Procedure
General procedure: A 25-mL sealable tube was charged with the appropriate aryliodide or bromide (1.0 mmol), dimethyl disulfide (1.2 mmol),Cu(OAc)2·H2O (0.1 mmol), KOH (2.0 mmol), TBAB (0.05 mmol),and H2O (2.0 mL). The mixture was stirred at 100 °C (130 °C forbromides) for 12 h under air then cooled to r.t. The mixture wasdiluted with H2O (5 mL) and extracted with EtOAc (4 × 10 mL).The extracts were combined, washed with brine (3 × 10 mL),dried (MgSO4), filtered, and concentrated. The residue was purifiedby chromatography [silica gel, EtOAc–hexane (1:30 to1:100)].
References:
Wang, Ying-Yu;Wu, Xiang-Mei;Yang, Ming-Hua [Synlett,2020] Location in patent:supporting information
624-92-0
352 suppliers
$20.62/5 mL
104-94-9
503 suppliers
$9.00/1g
1879-16-9
125 suppliers
$10.00/1g
3517-99-5
28 suppliers
inquiry
1879-16-9
125 suppliers
$10.00/1g
696-62-8
356 suppliers
$5.00/1g
67-68-5
1288 suppliers
$15.00/100g
1879-16-9
125 suppliers
$10.00/1g
93-58-3
506 suppliers
$13.50/100 mL
696-62-8
356 suppliers
$5.00/1g
1879-16-9
125 suppliers
$10.00/1g