1-Chloroadamantane synthesis
- Product Name:1-Chloroadamantane
- CAS Number:935-56-8
- Molecular formula:C10H15Cl
- Molecular Weight:170.68
768-95-6
435 suppliers
$10.00/5g
935-56-8
193 suppliers
$34.50/5g
Yield: 100%
Reaction Conditions:
with oxalyl dichloride;N,N-dimethyl-formamide in dichloromethane at 20; for 18 h;
Steps:
1 Scheme 1.
Adamantane acetic acid (1.6 g, 8.2 mmol) was dissolved in 20 mL dichloromethane and treated with dimethylformamide (2 drops) and oxalyl chloride (2.1 mL, 24.7 mmol) dropwise. The reaction was stirred at ambient temperature for 18 hours, concentrated in vacuo, and placed under hard vacuum overnight to yield the product as an oil (quant.).
References:
SPG THERAPEUTICS, INC.;SHAPOSHNIK, Zory WO2018/204422, 2018, A1 Location in patent:Paragraph 137
828-51-3
424 suppliers
$10.00/5g
935-56-8
193 suppliers
$34.50/5g
281-23-2
493 suppliers
$5.00/25g
935-56-8
193 suppliers
$34.50/5g
281-23-2
493 suppliers
$5.00/25g
935-56-8
193 suppliers
$34.50/5g
7346-41-0
42 suppliers
$198.00/250mg
