1-Boc-3-oxopiperazine synthesis
- Product Name:1-Boc-3-oxopiperazine
- CAS Number:76003-29-7
- Molecular formula:C9H16N2O3
- Molecular Weight:200.23
5625-67-2
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24424-99-5
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76003-29-7
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Yield:76003-29-7 100%
Reaction Conditions:
in dichloromethane for 3 h;
Steps:
33
To a mixture of piperazine-2-one (1.037 g, 10.4 mmol) in 52 mL of CH2Cl2, was added BOC20 (2.5 g, 11.4 mmol). The reaction became homogeneous after 3 hours when the starting material was completely consumed. The reaction was diluted with CH2Cl2 and the organic layer was washed with water. The solvent was removed in vacuo to yield quantitative amount of product 33 as a white solid. 1H NMR (300 MHz, CDCl3) 8 1.48 (s, 9H), 3.35-3.44 (m, 2H), 3.64 (t, 2H, J= 5 Hz), 4.10 (s, 2H), 6.41 (br s, 1H).
References:
GILEAD SCIENCES, INC.;CAI, Zhenhong, R.;CHEN, Xiaowu;FARDIS, Maria;JABRI, Salman, Y.;JIN, Haolun;KIM, Choung, U.;METOBO, Sanuel, E.;MISH, Michael, R.;PASTOR, Richard, M. WO2005/117904, 2005, A2 Location in patent:Page/Page column 407
24424-99-5
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105-39-5
414 suppliers
$10.00/5g
76003-29-7
242 suppliers
$5.00/5g
5625-67-2
341 suppliers
$5.00/1g
24424-99-5
858 suppliers
$13.50/25G
107-06-2
439 suppliers
$14.00/25g
76003-29-7
242 suppliers
$5.00/5g
24424-99-5
858 suppliers
$13.50/25G
76003-29-7
242 suppliers
$5.00/5g