午夜插插,噜噜噜影院,啪啪伊人网,欧美熟夫,景甜吻戏视频,男人强操性感蕾丝美女视频在线网站,日本美女跳舞视频

Welcome to chemicalbook!
Chinese English Japanese Germany Korea
400-158-6606
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

ChemicalBook CAS DataBase List 1-Benzyl-4-hydroxypiperidine
4727-72-4

1-Benzyl-4-hydroxypiperidine synthesis

6synthesis methods
-

Yield:4727-72-4 79%

Reaction Conditions:

with caesium carbonate in acetone;toluene at 20; for 24 h;

Steps:

3.2.1. General procedure for alkylation of piperidine nitrogen with propargyl bromide and benzyl bromide (general procedure 1)
General procedure: The piperidine (1.0 equiv.) was dissolved in acetone at room temperature. The solution was stirred and Cs2CO3 (1.0 equiv.) was added, followed by propargyl bromide (80 wt% solution in toluene, 1.0 equiv.) or benzyl bromide (1.0 equiv.). When propargyl bromide was used, the reaction mixture was protected from light by wrapping the flask with aluminium foil. After 24 h, the reaction mixture was filtered with suction, and the filtrate evaporated. The crude product was purified by flash column chromatography.

References:

Brazzolotto, Xavier;Gobec, Stanislav;Knez, Damijan;Kos, Janko;Nachon, Florian;?akelj, Simon;Juki?, Marko;Ko?ak, Urban;Pi?lar, Anja;Stra?ek, Nika;Zahirovi?, Abida [European Journal of Medicinal Chemistry,2020,vol. 197] Location in patent:supporting information

FullText

1-Benzyl-4-hydroxypiperidine Related Search: